Research

GEOHealth Health Effects of Selected Environmental Exposomes across the Life CourSe (HEALS) - India
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Objectives

  • Study the effect of environmental exposomes: PM2.5, NO2, O3, and extremes of temperature on multiple health outcomes through a modified life course approach

  • To obtain the exposomes at fine spatiotemporal resolutions across  7 different locations in India

U01 (Research): Exposure Assessment

Aim 1. To assess environmental exposomes (PM2.5, NO2, O3, and extremes of temperature) for 7 cities

Aim 1A. Machine learning-based predictive models at fine spatio-temporal resolutions (spatial:100m-1km, temporal: daily)

Aim 1B. Predictive models for speciated PM2.5 using ground monitoring-based measurements, ambient PM2.5, meteorology, and land use patterns

Pilot Aim 1: Real time personal environmental exposome measurements at individual levels & assess the extent of exposure error and evaluate exposure inequalities

U01 (Research): Health Associations

Aim 2. Assess associations between selected exposures and chronic non-communicable diseases across the life course

Pregnancy & child cohorts:

  • Pregnancy-related complications (gestational diabetes, pre-eclampsia)

  • Adverse birth and childhood outcomes (pre-term birth, low birth weight, and cognitive development)

Adolescent cohorts:

  • Glucose- insulin metabolism (HOMA-B, HOMA-IR, DI)

  • BP and arterial stiffness

  • Early life factors (birth anthropometry and subsequent growth trajectories) in modifying this relationship

Adult cohorts:

 

Incident

  • Hypertension,

  • Type 2 diabetes mellitus

  • CVD and CV and total mortality

Older adult and aging cohorts:

  • Age related and neuro-degenerative outcomes (cognitive decline, muscle strength, short physical performance battery test and frailty index)

Modified life course approach in GEOHealth Heals

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Hub Partners

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